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Proc. Natl. Acad. Sci. USA Vol. 85, pp. 2444-2448, April 1988 Biochemistry ... (amino acid/nucleic acid/data base searches/local similarity) ... WILLIAM R. PEARSON* AND DAVID J. LIPMANt ... *Department of Biochemistry, University of... more
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Large phylogenomics data sets require fast tree inference methods, especially for maximum-likelihood (ML) phylogenies. Fast programs exist, but due to inherent heuristics to find optimal trees, it is not clear whether the best tree is... more
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Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture. Most variants identified so far confer... more
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