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      Biology, Cell Cycle, Cell Biology, System Biology
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    • Cell Biology
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      Chemistry, Cell Biology, Ultrastructure
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      Biology, Immunohistochemistry, Cell Biology, Confocal Microscopy
Normal development requires tight regulation of cell proliferation and cell death. Here, we have investigated these control mechanisms in the hyaloid vessels, a temporary vascular network in the mammalian eye that requires a Wnt/β-catenin... more
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      Biology, Cell Biology, Apoptosis, Development
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      Cell Biology, Medicine, Clinical Sciences, Public health systems and services research
Thrombospondins are a family of stress-inducible secreted glycoproteins that underlie tissue remodeling. We recently reported that thrombospondin-4 (Thbs4) has a critical intracellular function, regulating the adaptive endoplasmic... more
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      Biology, Cell Biology, Endoplasmic Reticulum Stress, Medicine
Plasma membrane calcium ATPases PMCA1 and PMCA4 regulate osteoclast differentiation and survival by regulating NFATc1 and NO.
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      Biology, Cell Biology, Apoptosis, Biological Sciences
The microenvironment of human mesenchymal stem cells (hMSCs) regulates their self-renewal and differentiation properties. Previously it was shown that hMSCs remained quiescent on soft (0.25 kPa) polyacrylamide (PA) gels but re-entered... more
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      Chemistry, Cell Cycle, Cell Biology, Cell
Dichamanetin is a C-benzylated flavanone isolated as a major secondary metabolite from Piper sarmentosum, a plant used as a spice in Southeast Asia. This study aimed to investigate the path through which dichamanetin exerts its... more
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      Cell Biology, Mitochondria, Apoptosis, Western blotting
Hydrogenated TiO<sub>2</sub> (H-TiO<sub>2</sub>) is touted as a viable visible light photocatalyst. We report a systematic study on the thermal stability of H-implanted TiO<sub>2</sub> using nuclear... more
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      Molecular Biology, Biotechnology, Cancer, PHOTOELECTRON SPECTROSCOPY
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      Biology, Cell Biology, Mitochondria, Biological Chemistry
Limbal epithelial stem cells (LESCs) maintain the corneal epithelium throughout life and are crucial for both corneal integrity and vision. In this study, LESCs were expanded in either a culture system using 3T3 feeder cells in growth... more
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      Biology, Cell Biology, Stem Cell
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      Biology, Cell Biology, Biological Sciences, The
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      Genetics, Aging, Biology, Cell Biology
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      Cognitive Science, Biology, Membrane Proteins, Immunohistochemistry
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      Biology, Cell Biology, Medicine, Signal Transduction
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      Chemistry, Biomedical Engineering, Cell Biology, Stem Cell Transplantation
The nuclear matrix is defined as the insoluble framework of the nucleus and has been implicated in the regulation of gene expression, the cell cycle, and nuclear structural integrity via linkage to intermediate filaments of the... more
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      Biology, Cell Biology, Biological Sciences, Hippocampus
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      Biology, Cell Biology, Medicine, Biochemistry and cell biology
The development of cancer is a multistep process involving mutations in proto-oncogenes, tumor suppressor genes, and other genes which control cell proliferation, telomere stability, angiogenesis, and other complex traits. Despite this... more
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      Biology, Cell Biology, Medicine, Biological Sciences
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      Cell Biology, HSP, Heat Shock Protein, Biochemistry and cell biology
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      Cell Biology, Podocyte, Clinical Investigation, Medical and Health Sciences
<p>(A) hESCs were fed with medium containing soluble FGF2 or FGF2 beads, 25 ugs of protein were loaded for each sample and pERK2 levels were assessed over the subsequent 48 hours by western blot (left panel), quantified by... more
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      Biochemistry, Developmental Biology, Cell Biology, Activation
Apoptosis occurs widely during brain development, and p73 transcription factors are thought to play essential roles in this process. The p73 transcription factors are present in two forms, the full length TAp73 and the N-terminally... more
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      Biology, Cell Biology, Medicine, Multidisciplinary
Electron cryo-tomography allows for high-resolution imaging of stereocilia in their native state. Because their actin filaments have a higher degree of order, we imaged stereocilia from mice lacking the actin crosslinker plastin 1 (PLS1).... more
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      Materials Science, Structural Biology, Cell Biology, Medicine
Cadherins mediate cohesive contacts between isotypic cells by homophilic interaction and prevent contact between heterotypic cells. Breast cancer cells neighboring endothelial cells (ECs) atypically express vascular endothelial... more
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      Chemistry, Cell Biology, Medicine, Cadherin
Strict regulation of DNA replication is essential to ensure proper duplication and segregation of chromosomes during the cell cycle, as its deregulation can lead to genomic instability and cancer. Thus, eukaryotic organisms have evolved... more
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      Biology, Cell Cycle, DNA replication, Cell Biology
One set of genes sufficient for transformation of primary human cells uses the combination of Ha-Ras-V12, the telomerase catalytic subunit hTERT, SV40 large tumor antigen (LT), and SV40 small tumor antigen (ST). Whereas SV40 LT... more
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      Immune response, Cancer, Biology, Cell Cycle
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      Sociology, Geography, Cancer, Virology
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      Physiology, Electrophysiology, Biology, Cell Biology
<p>Motherisk safety guidelines for codeine use in breastfeeding pamphlet given to all expectant mothers with planned caesarean sections at St. Michaels Hospital in Toronto, Ontario, Canada (14). Women were advised to take codeine... more
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      Neuroscience, Developmental Biology, Immunology, Mental Health
<p>The influence of clinical factors on neonatal sedation (Infant ADR).</p
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      Neuroscience, Developmental Biology, Immunology, Mental Health
Dendritic cells are professional phagocytes that are highly specialized to process and present antigens from internalized particles to prime naïve T cells. To achieve their functions, the phagocytic machinery and membrane dynamics of... more
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      Fluorescence Microscopy, Biology, Membrane Trafficking, Cell Biology
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      Immunology, Biology, Cell Biology, Dendritic Cells
Questionnaire on use of cam by pregnant women. (DOCX 19Â kb)
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      Science Policy, Molecular Biology, Complementary and Alternative Medicine, Biotechnology
Abstract. Inhibition of cytokinesis by cytochalasins with-out an effect on karyokinesis has been demonstrated in several types of cells. We report here that treating crane-fly spermatocytes with cytochalasins at concentra-tions (10 gM CE,... more
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      Genetics, Biology, Cell Biology, Cell Division
<p><sup>1</sup> None of these women presented with any particular risk profile according to their screening data; <sup>2</sup> Unrelated to the intervention <sup>3</sup> LTFU: lost to... more
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      Evolutionary Biology, Neuroscience, Sociology, Immunology
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      Evolutionary Biology, Neuroscience, Immunology, Mental Health
<p>From insemination until 7 months of gestation, pregnant mares were managed as one same herd in the same pasture. From the 7<sup>th</sup> month of gestation, they were housed in individual boxes and allocated to one of... more
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      Biochemistry, Genetics, Physiology, Developmental Biology
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      Physiology, Chemistry, MicroRNA, Cell Biology
Contact sites between the mitochondria and endoplasmic reticulum (ER) are irregulates the exchange of lipids, Ca2+, and reactive oxygen species (ROS) across the two organelles. Mitofusin 2 (Mfn2) has been shown as one of the major... more
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      Chemistry, Biology, Cell Biology, Phosphorylation
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      Biochemistry, Physiology, Biophysics, Plasma Physics
Mesoderm induction assays in Xenopus have implicated growth factors such as activin, Vg1, Xwnt-8, and noggin as important in directing the formation of dorsal mesoderm (Spemann's organizer). Because these growth factors are... more
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      Biology, Cell Biology, Transcription Factors, Medicine
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      Plant Biology, Biology, Cell Biology, Medicine
Objective Transforming growth factor beta/single mothers against decapentaplegic (TGFβ/SMAD) signaling pathway plays important roles in various biological processes. It acts as a tumor suppressor during the early stages of cancer... more
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      Biology, Cell Biology, Medicine, Smad 3
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      Biology, Cell Biology, Oxidative Stress, Oncogene
β-catenin is a multifunctional protein that plays crucial roles in embryonic development, physiological homeostasis, and a wide variety of human cancers. Previously, we showed that in vivo targeted ablation of β-catenin in... more
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      Cell Biology, Cancer Research, Regulator
<p>Complete intermediate particle data in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0169895#pone.0169895.t001" target="_blank">Table 1</a>. The outer collector signal is... more
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      Biochemistry, Evolutionary Biology, Microbiology, Biophysics
OI is a clinically and genetically heterogeneous disorder characterized by bone fragility. More than 90% of patients are heterozygous for mutations in type I collagen genes, COL1A1 and COL1A2, and a common mutation is substitution for an... more
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      Biochemistry, Evolutionary Biology, Genetics, Biophysics